| http://purl.uniprot.org/citations/17294405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17294405 | http://www.w3.org/2000/01/rdf-schema#comment | "Proinflammatory cytokine IL-23 but not IL-12 is critical for the pathogenesis of organ-specific autoimmune diseases including experimental autoimmune encephalitis and collagen-induced arthritis. The contribution by IL-23 in systemic autoimmune diseases such as lupus is undefined. We addressed this question in a murine lupus-like disease model, initiated by enforced cell-surface expression of an ER HSP gp96 in C57BL/6 background. We found a significant increase of p40 in the sera in these mice that preceded the onset of diseases. However, autoimmunity was abrogated in transgenic mice expressing membrane-bound gp96 reconstituted with p35-/- BM, but not with p19-/-BM. Moreover, we found that dendritic cells (DC) but not macrophages were the main producers of p40. To dissect the roles of DC further, we depleted DC using a diphtheria toxin-based inducible DC depletion system. We demonstrated that the integrity of DC was essential for autoimmunity. Our results thus revealed that IL-12 and DC are critical for the pathogenesis of lupus-like disease precipitated by cell surface gp96. This study further highlighted the significant biological differences between IL-12 and IL-23."xsd:string |
| http://purl.uniprot.org/citations/17294405 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200636643"xsd:string |
| http://purl.uniprot.org/citations/17294405 | http://purl.uniprot.org/core/author | "Liu B."xsd:string |
| http://purl.uniprot.org/citations/17294405 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/17294405 | http://purl.uniprot.org/core/author | "Dai J."xsd:string |
| http://purl.uniprot.org/citations/17294405 | http://purl.uniprot.org/core/author | "Cua D.J."xsd:string |
| http://purl.uniprot.org/citations/17294405 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17294405 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17294405 | http://purl.uniprot.org/core/pages | "706-715"xsd:string |
| http://purl.uniprot.org/citations/17294405 | http://purl.uniprot.org/core/title | "Essential roles of IL-12 and dendritic cells but not IL-23 and macrophages in lupus-like diseases initiated by cell surface HSP gp96."xsd:string |
| http://purl.uniprot.org/citations/17294405 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P08113-mappedCitation-17294405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17294405 |
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| http://purl.uniprot.org/uniprot/#_Q9EQ14-mappedCitation-17294405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17294405 |
| http://purl.uniprot.org/uniprot/#_Q8CCY5-mappedCitation-17294405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17294405 |
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