| http://purl.uniprot.org/citations/17296016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17296016 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies point to a major role for alpha2-containing GABA-A receptors in modulating anxiety. However, the possible implication of GABA-A receptors containing the alpha3 subunit on anxiety is less known. The aim of this study was to examine the effects of SB-205384 (0.5-4 mg/kg, i.p.), an alpha3 subunit positive modulator of GABA-A receptor, on anxiety tested in the elevated plus-maze in male mice, using classical and ethological parameters. Mice treated with SB-205384 showed an increase in the frequency of entries and the time spent in open arms, as well as a reduction in the time spent in closed arms, as compared with the control group. A notable increase of "head-dipping" unprotected and a reduction of "stretched-attend posture" protected was also evident. These findings indicate that SB-205384 exhibits an anxiolytic-like profile in the elevated plus-maze test, suggesting that GABA-A receptors which contain the alpha3 subunit might be involved in regulation of anxiety."xsd:string |
| http://purl.uniprot.org/citations/17296016 | http://purl.uniprot.org/core/author | "Navarro J.F."xsd:string |
| http://purl.uniprot.org/citations/17296016 | http://purl.uniprot.org/core/author | "Buron E."xsd:string |
| http://purl.uniprot.org/citations/17296016 | http://purl.uniprot.org/core/author | "Martin-Lopez M."xsd:string |
| http://purl.uniprot.org/citations/17296016 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/17296016 | http://purl.uniprot.org/core/name | "Psicothema"xsd:string |
| http://purl.uniprot.org/citations/17296016 | http://purl.uniprot.org/core/pages | "100-104"xsd:string |
| http://purl.uniprot.org/citations/17296016 | http://purl.uniprot.org/core/title | "Anxiolytic-like activity of SB-205384 in the elevated plus-maze test in mice."xsd:string |
| http://purl.uniprot.org/citations/17296016 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/17296016 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17296016 |
| http://purl.uniprot.org/citations/17296016 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17296016 |
| http://purl.uniprot.org/uniprot/#_P26049-mappedCitation-17296016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17296016 |
| http://purl.uniprot.org/uniprot/#_Q8CAB3-mappedCitation-17296016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17296016 |
| http://purl.uniprot.org/uniprot/Q8CAB3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17296016 |
| http://purl.uniprot.org/uniprot/P26049 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17296016 |