| http://purl.uniprot.org/citations/17296785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17296785 | http://www.w3.org/2000/01/rdf-schema#comment | "A large proportion of Wiskott-Aldrich syndrome (WAS) patients develop autoimmunity and allergy. CD4(+)CD25(+)FOXP3(+) natural regulatory T (nTreg) cells play a key role in peripheral tolerance to prevent immune responses to self-antigens and allergens. Therefore, we investigated the effect of WAS protein (WASP) deficiency on the distribution and suppressor function of nTreg cells. In WAS(-/-) mice, the steady-state distribution and phenotype of nTreg cells in the thymus and spleen were normal. However, WAS(-/-) nTreg cells engrafted poorly in immunized mice, indicating perturbed homeostasis. Moreover, WAS(-/-) nTreg cells failed to proliferate and to produce transforming growth factor beta upon T cell receptor (TCR)/CD28 triggering. WASP-dependent F-actin polarization to the site of TCR triggering might not be involved in WAS(-/-) nTreg cell defects because this process was also inefficient in wild-type (WT) nTreg cells. Compared with WT nTreg cells, WAS(-/-) nTreg cells showed reduced in vitro suppressor activity on both WT and WAS(-/-) effector T cells. Similarly, peripheral nTreg cells were present at normal levels in WAS patients but failed to suppress proliferation of autologous and allogeneic CD4(+) effector T cells in vitro. Thus, WASP appears to play an important role in the activation and suppressor function of nTreg cells, and a dysfunction or incorrect localization of nTreg cells may contribute to the development of autoimmunity in WAS patients."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20061334"xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Villa A."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Notarangelo L.D."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Aiuti A."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Martino S."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Roncarolo M.G."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Scaramuzza S."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Metin A."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Dupre L."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Battaglia M."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Cattaneo F."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Marangoni F."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Trifari S."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Baz Z."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/author | "Panaroni C."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/pages | "369-380"xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/title | "WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/17296785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17296785 |
| http://purl.uniprot.org/citations/17296785 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17296785 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TM35-mappedCitation-17296785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17296785 |