| http://purl.uniprot.org/citations/17296929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17296929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17296929 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Catenins are conserved regulators of metazoan development that function with TCF DNA-binding proteins to activate transcription. In Caenorhabditis elegans, SYS-1/beta-catenin and POP-1/TCF regulate several asymmetric divisions, including that of the somatic gonadal precursor cell (SGP). In the distal but not the proximal SGP daughter, SYS-1/beta-catenin and POP-1/TCF transcriptionally activate ceh-22 to specify the distal fate. Here, we investigate the distribution of SYS-1/beta-catenin and its regulation. Using a rescuing transgene, VNS::SYS-1, which fuses VENUS fluorescent protein to SYS-1, we find more VNS::SYS-1 in distal than proximal SGP daughters, a phenomenon we call "SYS-1 asymmetry." In addition, SYS-1 asymmetry is seen in many other tissues, consistent with the idea that SYS-1 regulates asymmetric divisions broadly during C. elegans development. In particular, SYS-1 is more abundant in E than MS, and SYS-1 is critical for the endodermal fate. In all cases, SYS-1 is reciprocal to POP-1 asymmetry: cells with higher SYS-1 have lower POP-1, and vice versa. SYS-1 asymmetry is controlled posttranslationally and relies on frizzled and dishevelled homologs, which also control POP-1 asymmetry. Therefore, upstream regulators modulate the SYS-1 to POP-1 ratio by increasing SYS-1 and decreasing POP-1 within the same cell. By contrast, SYS-1 asymmetry does not rely on WRM-1, which appears specialized for POP-1 asymmetry. We suggest a two-pronged pathway for control of SYS-1:POP-1, which can robustly accomplish differential gene expression in daughters of an asymmetric cell division."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0611507104"xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0611507104"xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/author | "King R."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/author | "King R."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/author | "Hardin J."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/author | "Hardin J."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/author | "Kimble J."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/author | "Kimble J."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/author | "Phillips B.T."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/author | "Phillips B.T."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/author | "Kidd A.R. III"xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/author | "Kidd A.R. III"xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/pages | "3231-3236"xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/pages | "3231-3236"xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/title | "Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/title | "Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/17296929 | http://purl.uniprot.org/core/volume | "104"xsd:string |