| http://purl.uniprot.org/citations/17296939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17296939 | http://www.w3.org/2000/01/rdf-schema#comment | "The joining of DNA ends during Ig class-switch recombination (CSR) is thought to involve the same nonhomologous end-joining pathway as used in V(D)J recombination. However, we reported earlier that CSR can readily occur in Ig transgenic SCID mice lacking DNA-dependent protein kinase (DNA-PK) activity, a critical enzymatic activity for V(D)J recombination. We were thus led to question whether the catalytic subunit of DNA-PK (DNA-PKcs) is essential for CSR. To address this issue, we asked whether class switching to different Ig isotypes could occur in a line of Ig transgenic mice lacking detectable DNA-PKcs protein. The answer was affirmative. We conclude that joining of DNA ends during CSR does not require DNA-PKcs and can occur by an alternative repair pathway to that used for V(D)J recombination."xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0611359104"xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/author | "Oshinsky J."xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/author | "Kiefer K."xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/author | "Bosma M.J."xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/author | "Nakajima P.B."xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/author | "Bosma G.C."xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/pages | "2843-2848"xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/title | "The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination."xsd:string |
| http://purl.uniprot.org/citations/17296939 | http://purl.uniprot.org/core/volume | "104"xsd:string |
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