| http://purl.uniprot.org/citations/17297443 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17297443 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated a novel interferon (IFN)-retinoid regulated cell death regulatory protein genes associated with retinoid-IFN-induced mortality (GRIM)-19 earlier. To understand its mechanism of action, we have employed a yeast-two-hybrid screen and identified serine protease HtrA2 as its binding partner. GRIM-19 physically interacts with HtrA2 and augments cell death in an IFN/all-trans retinoic acid (RA)-dependent manner. In the presence of GRIM-19, the HtrA2-driven destruction of the antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) is augmented. These interactions were disrupted by an human herpes virus-8 (HHV-8)-coded oncoprotein, vIRF1, and conferred resistance to IFN/RA-induced cell death. These data show a critical role of HtrA2 in a cytokine-induced cell death response for the first time and its inhibition by a viral protein."xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1210287"xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/author | "Srinivasula S.M."xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/author | "Reddy S.P."xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/author | "Kalvakolanu D.V."xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/author | "Platanias L.C."xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/author | "Kalakonda S."xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/pages | "4842-4849"xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/title | "GRIM-19 associates with the serine protease HtrA2 for promoting cell death."xsd:string |
| http://purl.uniprot.org/citations/17297443 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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