| http://purl.uniprot.org/citations/17301159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17301159 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibition of matrix metalloproteinase-9 (MMP-9) protects the adult brain after cerebral ischemia. However, the role of MMP-9 in the immature brain after hypoxia-ischemia (HI) is unknown. We exposed MMP-9(-/-) [MMP-9 knock-out (KO)] and wild-type (WT) mice to HI on postnatal day 9. HI was induced by unilateral ligation of the left carotid artery followed by hypoxia (10% O2; 36 degrees C). Gelatin zymography showed that MMP-9 activity was transiently increased at 24 h after HI in the ipsilateral hemisphere and MMP-9-positive cells were colocalized with activated microglia. Seven days after 50 min of HI, cerebral tissue volume loss was reduced in MMP-9 KO (21.8 +/-1.7 mm3; n = 22) compared with WT (32.3 +/-2.1 mm3; n = 22; p < 0.001) pups, and loss of white-matter components was reduced in MMP-9 KO compared with WT pups (neurofilament: WT, 50.9 +/-5.4%; KO, 18.4 +/- 3.1%; p < 0.0001; myelin basic protein: WT, 57.5 +/-5.8%; KO, 23.2 +/-3.5%; p = 0.0001). The neuropathological changes were associated with a delayed and diminished leakage of the blood-brain barrier (BBB) and a decrease in inflammation in MMP-9-deficient animals. In contrast, the neuroprotective effects after HI in MMP-9-deficient animals were not linked to either caspase-dependent (caspase-3 and cytochrome c) or caspase-independent (apoptosis-inducing factor) processes. This study demonstrates that excessive activation of MMP-9 is deleterious to the immature brain, which is associated with the degree of BBB leakage and inflammation. In contrast, apoptosis does not appear to be a major contributing factor."xsd:string |
| http://purl.uniprot.org/citations/17301159 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4391-06.2007"xsd:string |
| http://purl.uniprot.org/citations/17301159 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/17301159 | http://purl.uniprot.org/core/author | "Hagberg H."xsd:string |
| http://purl.uniprot.org/citations/17301159 | http://purl.uniprot.org/core/author | "Mallard C."xsd:string |
| http://purl.uniprot.org/citations/17301159 | http://purl.uniprot.org/core/author | "Savman K."xsd:string |
| http://purl.uniprot.org/citations/17301159 | http://purl.uniprot.org/core/author | "Svedin P."xsd:string |
| http://purl.uniprot.org/citations/17301159 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17301159 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/17301159 | http://purl.uniprot.org/core/pages | "1511-1518"xsd:string |
| http://purl.uniprot.org/citations/17301159 | http://purl.uniprot.org/core/title | "Matrix metalloproteinase-9 gene knock-out protects the immature brain after cerebral hypoxia-ischemia."xsd:string |
| http://purl.uniprot.org/citations/17301159 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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