| http://purl.uniprot.org/citations/17301675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17301675 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcriptional regulation is central to the long-term effects of drugs of abuse. Activation of the extracellular signal-regulated kinase (ERK1/2) pathway underlies plasticity changes that accompany drug use. One target of ERK1/2 activation is the Ets-like transcription factor Elk-1. We show here that nicotine modulates Elk-1 in the rat hippocampus in a spatially and temporally specific manner. In-vitro nicotine (1 muM) activated Elk-1 in hippocampal slices. In-vivo acute nicotine (0.4 mg/kg) activated Elk-1 in the CA1 area but not in the dentate gyrus. Chronic nicotine for 14 days changed the level of total Elk-1 but not its phosphorylation state. Thus, Elk-1 regulation of transcriptional events may contribute to nicotine-induced changes in the hippocampus."xsd:string |
| http://purl.uniprot.org/citations/17301675 | http://purl.org/dc/terms/identifier | "doi:10.1097/wnr.0b013e328010a1ff"xsd:string |
| http://purl.uniprot.org/citations/17301675 | http://purl.uniprot.org/core/author | "Wonnacott S."xsd:string |
| http://purl.uniprot.org/citations/17301675 | http://purl.uniprot.org/core/author | "Jones I.W."xsd:string |
| http://purl.uniprot.org/citations/17301675 | http://purl.uniprot.org/core/author | "Barik J."xsd:string |
| http://purl.uniprot.org/citations/17301675 | http://purl.uniprot.org/core/author | "Nuutinen S."xsd:string |
| http://purl.uniprot.org/citations/17301675 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17301675 | http://purl.uniprot.org/core/name | "Neuroreport"xsd:string |
| http://purl.uniprot.org/citations/17301675 | http://purl.uniprot.org/core/pages | "121-126"xsd:string |
| http://purl.uniprot.org/citations/17301675 | http://purl.uniprot.org/core/title | "Differential effects of acute and chronic nicotine on Elk-1 in rat hippocampus."xsd:string |
| http://purl.uniprot.org/citations/17301675 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/17301675 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17301675 |
| http://purl.uniprot.org/citations/17301675 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17301675 |
| http://purl.uniprot.org/uniprot/#_A4GTP4-mappedCitation-17301675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17301675 |
| http://purl.uniprot.org/uniprot/A4GTP4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17301675 |