| http://purl.uniprot.org/citations/17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17302911 | http://www.w3.org/2000/01/rdf-schema#comment | "N-ethylmaleimide-sensitive fusion protein (NSF) is essential for numerous Ca(2+)-triggered vesicle trafficking events. It functions as a molecular chaperone to regulate trafficking protein complexes such as the soluble NSF attachment protein (SNAP) receptor complex and the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-protein interacting with C-kinase (PICK1) complex. AMPAR trafficking is fundamental to processes of synaptic plasticity, which may underlie learning and memory. Changes in synaptic strength brought about by AMPAR trafficking are triggered by a post-synaptic influx of Ca(2+), which may have numerous molecular targets including PICK1. NSF binds AMPAR subunit glutamate receptor subunit 2 (GluR2) and functions to maintain receptors at the synapse. In this study, it was showed that NSF is a Ca(2+)-binding protein and that GluR2-NSF interactions are inhibited by the presence of 15 mumol/L Ca(2+). NSF Ca(2+)-binding is reciprocally inhibited by the presence of GluR2 C-terminus. Mutant of NSF that binds Ca(2+) with reduced affinity and binds GluR2 with reduced sensitivity to Ca(2+) was identied. In addition, the interaction of betaSNAP with PICK1 is sensitive to Ca(2+). This study demonstrates that the GluR2-NSF-betaSNAP-PICK1 complex is regulated directly by Ca(2+), allowing for the transduction of Ca(2+) signals into concerted alterations in protein-protein interactions to bring about changes in AMPAR trafficking during synaptic plasticity."xsd:string |
| http://purl.uniprot.org/citations/17302911 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2007.04455.x"xsd:string |
| http://purl.uniprot.org/citations/17302911 | http://purl.uniprot.org/core/author | "Hanley J.G."xsd:string |
| http://purl.uniprot.org/citations/17302911 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17302911 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/17302911 | http://purl.uniprot.org/core/pages | "1644-1650"xsd:string |
| http://purl.uniprot.org/citations/17302911 | http://purl.uniprot.org/core/title | "NSF binds calcium to regulate its interaction with AMPA receptor subunit GluR2."xsd:string |
| http://purl.uniprot.org/citations/17302911 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/17302911 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17302911 |
| http://purl.uniprot.org/citations/17302911 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17302911 |
| http://purl.uniprot.org/uniprot/#_A6J5S9-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_A6J5T0-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_A6HJT2-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_A6HJT3-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_A6HSQ5-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_A6HSQ7-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_A6HSQ8-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_A6HSQ9-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_Q71V86-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_O88960-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_O88975-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_P19491-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_Q9QUL6-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |
| http://purl.uniprot.org/uniprot/#_Q9EP80-mappedCitation-17302911 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17302911 |