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http://purl.uniprot.org/citations/17304884http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17304884http://www.w3.org/2000/01/rdf-schema#comment"

Background

Genetic susceptibility to common variable immunodeficiency (CVID) has been linked to the inheritance of part or all of 2 extended major histocompatibility complex haplotypes: HLA*B8*DR3(17) and HLA*B44*DR7.

Objective

To determine whether the inheritance of these major histocompatibility complex susceptibility haplotypes correlates with absolute B-cell numbers.

Methods

A retrospective medical record review of 55 consecutive patients with CVID whose blood was analyzed for B-cell numbers using a fluorescent-activated cell sorter.

Results

The mean +/-SD absolute count of CD19+ B cells among the 36 patients (65%) with CVID who had inherited HLA*B8 or HLA*B44 was 218 +/- 23 cells/mm3 compared with 119 +/-27 cells/mm3 in those who had not inherited HLA*B8 or HLA*B44 (P = .008). There were no significant differences in B-cell numbers among the 33 patients (60%) with CVID who had inherited HLA*DR7 or HLA*DR3(17) and those who had not.

Conclusions

Patients with CVID who inherited HLA*B44 or HLA*B8 tended to have higher numbers of B cells in the blood than those who did not, suggesting that the mechanism of immunodeficiency may differ."xsd:string
http://purl.uniprot.org/citations/17304884http://purl.org/dc/terms/identifier"doi:10.1016/s1081-1206(10)60690-4"xsd:string
http://purl.uniprot.org/citations/17304884http://purl.uniprot.org/core/author"Johnston D.T."xsd:string
http://purl.uniprot.org/citations/17304884http://purl.uniprot.org/core/author"Schroeder H.W. Jr."xsd:string
http://purl.uniprot.org/citations/17304884http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17304884http://purl.uniprot.org/core/name"Ann Allergy Asthma Immunol"xsd:string
http://purl.uniprot.org/citations/17304884http://purl.uniprot.org/core/pages"163-167"xsd:string
http://purl.uniprot.org/citations/17304884http://purl.uniprot.org/core/title"B-cell numbers in the blood of patients with non-HLA*B8 or non-HLA*B44 common variable immunodeficiency."xsd:string
http://purl.uniprot.org/citations/17304884http://purl.uniprot.org/core/volume"98"xsd:string
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