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Objectives

We explored a potential association between nasal polyps (NPs) and polymorphism at loci for human leukocyte antigen (HLA) DR and HLA-DQ.

Methods

Polymorphism at loci HLA-DR and HLA-DQ were examined in 30 patients with NPs and in 81 healthy subjects by use of the polymerase chain reaction-sequence specific primer method.

Results

HLA-DR16, HLA-DQ8, and HLA-DQ9 were found to be significantly associated with NPs. HLA-DR16, HLA-DQ8, and HLA-DQ9 specificities were found at higher frequencies in patients with NPs than in control subjects (5% versus 0.62%, RR = 8.9, p = .03; 10% versus 2.47%, RR = 4.81, p = .01; and 20% versus 6.18%, RR = 4.73%, p = .001; respectively). In contrast, HLA-DQ7 was found at lower frequencies in patients with NPs than in controls (10% versus 20.37%, RR = 0.36, p = .04).

Conclusions

We conclude that HLA-DR16, HLA-DQ8, and HLA-DQ9 represent potential susceptibility determinants and that HLA-DQ7 might confer resistance in nasal polyps."xsd:string
http://purl.uniprot.org/citations/17305280http://purl.org/dc/terms/identifier"doi:10.1177/000348940711600111"xsd:string
http://purl.uniprot.org/citations/17305280http://purl.uniprot.org/core/author"Liu H."xsd:string
http://purl.uniprot.org/citations/17305280http://purl.uniprot.org/core/author"Sun Y."xsd:string
http://purl.uniprot.org/citations/17305280http://purl.uniprot.org/core/author"Tang L."xsd:string
http://purl.uniprot.org/citations/17305280http://purl.uniprot.org/core/author"Zhai L."xsd:string
http://purl.uniprot.org/citations/17305280http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17305280http://purl.uniprot.org/core/name"Ann Otol Rhinol Laryngol"xsd:string
http://purl.uniprot.org/citations/17305280http://purl.uniprot.org/core/pages"66-68"xsd:string
http://purl.uniprot.org/citations/17305280http://purl.uniprot.org/core/title"Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps."xsd:string
http://purl.uniprot.org/citations/17305280http://purl.uniprot.org/core/volume"116"xsd:string
http://purl.uniprot.org/citations/17305280http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17305280
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