| http://purl.uniprot.org/citations/17306224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17306224 | http://www.w3.org/2000/01/rdf-schema#comment | "Recurrent chromosomal rearrangements at BCL11B are found in human hematopoietic malignancies mostly of T-cell origin. However, it is unclear how this disruption contributes to oncogenesis, because the majority of leukemias express BCL11B from an undisrupted allele. Here, we show that Bcl11b(+/-)p53(+/-) mice exhibited greater susceptibility to lymphomas than Bcl11b(+/+)p53(+/-) mice but most lymphomas retained and expressed the wild-type Bcl11b allele. This strongly suggests that Bcl11b is haploinsufficient for suppression of thymic lymphoma development in mice of the p53(+/-) background, a situation in which functional loss of only one allele confers a selective advantage for tumor growth. The haploinsufficiency is further supported by that Bcl11b(+/-) mouse embryos were impaired in thymocyte development and survival. These results indicate relevance of BCL11B aberration to human leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.02.003"xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/author | "Mishima Y."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/author | "Kamimura K."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/author | "Kubota T."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/author | "Wakabayashi Y."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/author | "Aoyagi Y."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/author | "Ohi H."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/author | "Kominami R."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/author | "Yoshikai Y."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/author | "Okazuka K."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/pages | "538-542"xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/title | "Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development."xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://purl.uniprot.org/core/volume | "355"xsd:string |
| http://purl.uniprot.org/citations/17306224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17306224 |
| http://purl.uniprot.org/citations/17306224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17306224 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E1-mappedCitation-17306224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17306224 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-17306224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17306224 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-17306224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17306224 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-17306224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17306224 |
| http://purl.uniprot.org/uniprot/#_P02340-mappedCitation-17306224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17306224 |
| http://purl.uniprot.org/uniprot/#_Q3UGQ1-mappedCitation-17306224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17306224 |