| http://purl.uniprot.org/citations/17307841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17307841 | http://www.w3.org/2000/01/rdf-schema#comment | "Lymphocyte apoptosis plays a central role in the pathophysiology of sepsis. Lymphocyte apoptosis was examined in mice with defective death receptor pathways due to transgenic expression of a dominant negative mutant of Fas-associated death domain (FADD-DN) or Bid-/- and in mice with defective mitochondrial-mediated pathways due to loss of Bim-/-, Puma-/-, or Noxa-/-. FADD-DN transgenic and Bid-/-mice had significant albeit incomplete protection, and this protection was associated with increased survival. Surprisingly, splenic B cells were also protected in FADD-DN mice although transgene expression was confined to T cells, providing evidence for an indirect protective mechanism. Bim-/-provided virtually complete protection against lymphocyte apoptosis whereas Puma-/- and Noxa-/- mice had modest or no protection, respectively. Bim-/-mice had improved survival, and adoptive transfer of splenocytes from Bim-/-mice into Rag 1-/-mice demonstrated that this was a lymphocyte intrinsic effect. The improved survival was associated with decreased interleukin (IL) -10 and IL-6 cytokines. Collectively, these data indicate that numerous death stimuli are generated during sepsis, and it therefore appears unlikely that blocking a single "trigger" can inhibit apoptosis. If siRNA becomes practical therapeutically, proapoptotic proteins would be potential targets."xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.06-6805com"xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/author | "Chang K.C."xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/author | "Strasser A."xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/author | "Hotchkiss R.S."xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/author | "Davis C.G."xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/author | "Muenzer J.T."xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/author | "Unsinger J."xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/author | "Schwulst S.J."xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/pages | "708-719"xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/title | "Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis."xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/17307841 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17307841 |
| http://purl.uniprot.org/citations/17307841 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17307841 |
| http://purl.uniprot.org/uniprot/#_D3Z2M5-mappedCitation-17307841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17307841 |
| http://purl.uniprot.org/uniprot/#_P70444-mappedCitation-17307841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17307841 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GR88-mappedCitation-17307841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17307841 |
| http://purl.uniprot.org/uniprot/#_A0A494BAM9-mappedCitation-17307841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17307841 |
| http://purl.uniprot.org/uniprot/#_A0A494BAU0-mappedCitation-17307841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17307841 |
| http://purl.uniprot.org/uniprot/#_B2RVL4-mappedCitation-17307841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17307841 |
| http://purl.uniprot.org/uniprot/#_D3Z463-mappedCitation-17307841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17307841 |
| http://purl.uniprot.org/uniprot/#_O54918-mappedCitation-17307841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17307841 |