| http://purl.uniprot.org/citations/17311849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17311849 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic studies in mice and humans have shown that the transforming growth factor-beta (TGF-beta) type-I receptor activin receptor-like kinase 1 (ALK1) and its co-receptor endoglin play an important role in vascular development and angiogenesis. Here, we demonstrate that ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed. Whereas BMP-9 predominantly bound to ALK1 and BMPR-II in ECs, it bound to ALK2 and BMPR-II in myoblasts. In addition, we observed binding of BMP-9 to ALK1 and endoglin in glioblastoma cells. BMP-9 activated Smad1 and/or Smad5, and induced ID1 protein and endoglin mRNA expression in ECs. Furthermore, BMP-9 was found to inhibit basic fibroblast growth factor (bFGF)-stimulated proliferation and migration of bovine aortic ECs (BAECs) and to block vascular endothelial growth factor (VEGF)-induced angiogenesis. Taken together, these results suggest that BMP-9 is a physiological ALK1 ligand that plays an important role in the regulation of angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.002949"xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/author | "Zhao Q."xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/author | "ten Dijke P."xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/author | "Scharpfenecker M."xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/author | "Lowik C.W."xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/author | "van Bezooijen R.L."xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/author | "Pukac L."xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/author | "van Dinther M."xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/pages | "964-972"xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/title | "BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/17311849 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17311849 |
| http://purl.uniprot.org/citations/17311849 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17311849 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z2Y4-mappedCitation-17311849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17311849 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z310-mappedCitation-17311849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17311849 |
| http://purl.uniprot.org/uniprot/#_P0AEX9-mappedCitation-17311849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17311849 |
| http://purl.uniprot.org/uniprot/#_B2RC63-mappedCitation-17311849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17311849 |
| http://purl.uniprot.org/uniprot/#_B4E0D4-mappedCitation-17311849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17311849 |
| http://purl.uniprot.org/uniprot/#_B4DUF0-mappedCitation-17311849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17311849 |
| http://purl.uniprot.org/uniprot/#_B4DPT9-mappedCitation-17311849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17311849 |