| http://purl.uniprot.org/citations/17312006 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17312006 | http://www.w3.org/2000/01/rdf-schema#comment | "Mouse strains AcB55 and AcB61 are resistant to malaria by virtue of a mutation in erythrocyte pyruvate kinase (Pklr(I90N)). Linkage analysis in [AcB55 x A/J] F2 mice detected a second locus (Char9; logarithm of odds = 4.74) that regulates the blood-stage replication of Plasmodium chabaudi AS independently of Pklr. We characterized the 77 genes of the Char9 locus for tissue-specific expression, strain-specific alterations in gene expression, and polymorphic variants that are possibly associated with differential susceptibility. We identified Vnn1/Vnn3 as the likely candidates responsible for Char9. Vnn3/Vnn1 map within a conserved haplotype block and show expression levels that are strictly cis-regulated by this haplotype. The absence of Vnn messenger RNA expression and lack of pantetheinase protein activity in tissues are associated with susceptibility to malaria and are linked to a complex rearrangement in the Vnn3 promoter region. The A/J strain also carries a unique nonsense mutation that leads to a truncated protein. Vanin genes code for a pantetheinase involved in the production of cysteamine, a key regulator of host responses to inflammatory stimuli. Administration of cystamine in vivo partially corrects susceptibility to malaria in A/J mice, as measured by reduced blood parasitemia and decreased mortality. These studies suggest that pantetheinase is critical for the host response to malaria."xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20061252"xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/author | "Gros P."xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/author | "Tam M."xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/author | "Fortin A."xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/author | "Pitari G."xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/author | "Stevenson M.M."xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/author | "Min-Oo G."xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/pages | "511-524"xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/title | "Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus."xsd:string |
| http://purl.uniprot.org/citations/17312006 | http://purl.uniprot.org/core/volume | "204"xsd:string |
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