| http://purl.uniprot.org/citations/17312021 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17312021 | http://www.w3.org/2000/01/rdf-schema#comment | "RAD51C is a member of the RecA/RAD51 protein family, which is known to play an important role in DNA repair by homologous recombination. In mice, it is essential for viability. Therefore, we have generated a hypomorphic allele of Rad51c in addition to a null allele. A subset of mice expressing the hypomorphic allele is infertile. This infertility is caused by sexually dimorphic defects in meiotic recombination, revealing its two distinct functions. Spermatocytes undergo a developmental arrest during the early stages of meiotic prophase I, providing evidence for the role of RAD51C in early stages of RAD51-mediated recombination. In contrast, oocytes can progress normally to metaphase I after superovulation but display precocious separation of sister chromatids, aneuploidy, and broken chromosomes at metaphase II. These defects suggest a possible late role of RAD51C in meiotic recombination. Based on the marked reduction in Holliday junction (HJ) resolution activity in Rad51c-null mouse embryonic fibroblasts, we propose that this late function may be associated with HJ resolution."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200608130"xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Tessarollo L."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Pellegrini M."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "West S.C."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Donovan P.J."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Pati D."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Nussenzweig A."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Sharan S.K."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Burkett S."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Martin B.K."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Fernandez-Capetillo O."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Southon E."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Kuznetsov S."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/author | "Shuda K."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/pages | "581-592"xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/title | "RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females."xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/17312021 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17312021 |
| http://purl.uniprot.org/citations/17312021 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17312021 |
| http://purl.uniprot.org/uniprot/Q924H5#attribution-7D7EFADE2091B7EB520843893AE56A86 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17312021 |