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http://purl.uniprot.org/citations/17314401http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17314401http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17314401http://www.w3.org/2000/01/rdf-schema#comment"The Golgi complex in mammalian cells forms a continuous ribbon of interconnected stacks of flat cisternae. We show here that this distinctive architecture reflects and requires the continuous input of membranes from the endoplasmic reticulum (ER), in the form of pleiomorphic ER-to-Golgi carriers (EGCs). An important step in the biogenesis of the Golgi ribbon is the complete incorporation of the EGCs into the stacks. This requires the Golgi-matrix protein GM130, which continuously cycles between the cis-Golgi compartments and the EGCs. On acquiring GM130, the EGCs undergo homotypic tethering and fusion, maturing into larger and more homogeneous membrane units that appear primed for incorporation into the Golgi stacks. In the absence of GM130, this process is impaired and the EGCs remain as distinct entities. This induces the accumulation of tubulovesicular membranes, the shortening of the cisternae, and the breakdown of the Golgi ribbon. Under these conditions, however, secretory cargo can still be delivered to the Golgi complex, although this occurs less efficiently, and apparently through transient and/or limited continuities between the EGCs and the Golgi cisternae."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.org/dc/terms/identifier"doi:10.1091/mbc.e06-10-0886"xsd:string
http://purl.uniprot.org/citations/17314401http://purl.org/dc/terms/identifier"doi:10.1091/mbc.e06-10-0886"xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"De Matteis M.A."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"De Matteis M.A."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Di Campli A."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Di Campli A."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Di Tullio G."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Di Tullio G."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Marra P."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Marra P."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Salvatore L."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Salvatore L."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Mironov A."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Mironov A."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Mironov A. Jr."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Mironov A. Jr."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Beznoussenko G."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Beznoussenko G."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Trucco A."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/author"Trucco A."xsd:string
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17314401http://purl.uniprot.org/core/date"2007"xsd:gYear