| http://purl.uniprot.org/citations/17314980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17314980 | http://www.w3.org/2000/01/rdf-schema#comment | "Defining the functional relationships between proteins is critical for understanding virtually all aspects of cell biology. Large-scale identification of protein complexes has provided one important step towards this goal; however, even knowledge of the stoichiometry, affinity and lifetime of every protein-protein interaction would not reveal the functional relationships between and within such complexes. Genetic interactions can provide functional information that is largely invisible to protein-protein interaction data sets. Here we present an epistatic miniarray profile (E-MAP) consisting of quantitative pairwise measurements of the genetic interactions between 743 Saccharomyces cerevisiae genes involved in various aspects of chromosome biology (including DNA replication/repair, chromatid segregation and transcriptional regulation). This E-MAP reveals that physical interactions fall into two well-represented classes distinguished by whether or not the individual proteins act coherently to carry out a common function. Thus, genetic interaction data make it possible to dissect functionally multi-protein complexes, including Mediator, and to organize distinct protein complexes into pathways. In one pathway defined here, we show that Rtt109 is the founding member of a novel class of histone acetyltransferases responsible for Asf1-dependent acetylation of histone H3 on lysine 56. This modification, in turn, enables a ubiquitin ligase complex containing the cullin Rtt101 to ensure genomic integrity during DNA replication."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature05649"xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Han J."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Krogan N.J."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Cheng B."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Brown G.W."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Ding H."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Berger S.L."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Maas N.L."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Schuldiner M."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Weissman J.S."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Andrews B."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Allis C.D."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Recht J."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Emili A."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Greenblatt J.F."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Hieter P."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Boone C."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Gebbia M."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Fillingham J."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Roguev A."xsd:string |
| http://purl.uniprot.org/citations/17314980 | http://purl.uniprot.org/core/author | "Shales M."xsd:string |