| http://purl.uniprot.org/citations/17317671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17317671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17317671 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the evolutionarily conserved Mastermind (MAM) protein family, including the three related mammalian Mastermind-like (MAML) proteins MAML1-3, function as crucial coactivators of Notch-mediated transcriptional activation. Given the recent evidence of cross-talk between the p53 and Notch signal transduction pathways, we have investigated whether MAML1 may also be a transcriptional coactivator of p53. Indeed, we show here that MAML1 is able to interact with p53. We show that MAML1-p53 interaction involves the N-terminal region of MAML1 and the DNA-binding domain of p53, and we use a chromatin immunoprecipitation assay to show that MAML1 is part of the activator complex that binds to native p53-response elements within the promoter of the p53 target genes. Overexpression of wild-type MAML1 as well as a mutant, defective in Notch signaling, enhanced the p53-dependent gene induction in mammalian cells, whereas MAML1 knockdown reduced the p53-dependent gene expression. MAML1 increases the half-life of p53 protein and enhances its phosphorylation/acetylation upon DNA damage of cells. Finally, RNA interference-mediated knockdown of the single Caenorhabditis elegans MAML homolog, Lag-3, led to substantial abrogation of p53-mediated germ-cell apoptotic response to DNA damage and markedly reduced the expression of Ced-13 and Egl-1, downstream pro-apoptotic targets of the C. elegans p53 homolog Cep-1. Thus, we present evidence for a novel coactivator function of MAML1 for p53, independent of its function as a coactivator of Notch signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m608974200"xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m608974200"xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Ma H."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Ma H."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Zeng M.S."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Zeng M.S."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Gao Q."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Gao Q."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Katzman R.B."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Katzman R.B."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Kung A."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Kung A."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Griffin J.D."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Griffin J.D."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Band V."xsd:string |
| http://purl.uniprot.org/citations/17317671 | http://purl.uniprot.org/core/author | "Band V."xsd:string |