| http://purl.uniprot.org/citations/17318177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17318177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17318177 | http://www.w3.org/2000/01/rdf-schema#comment | "In mammalian RNA polymerase I transcription, SL1, an assembly of TBP and associated factors (TAFs), is essential for preinitiation complex formation at ribosomal RNA gene promoters in vitro. We provide evidence for a novel component of SL1, TAF(I)41 (MGC5306), which functions in Pol I transcription. TAF(I)41 resides at the rDNA promoter in the nucleolus and co-purifies and co-immunoprecipitates with SL1. TAF(I)41 immunodepletion from nuclear extracts dramatically reduces Pol I transcription; addition of SL1 restores the ability of these extracts to support Pol I transcription. In cells, siRNA-mediated decreased expression of TAF(I)41 leads to loss of SL1 from the rDNA promoter in vivo, with concomitant loss of Pol I from the rDNA and reduced synthesis of the pre-rRNA. Extracts from these cells support reduced levels of Pol I transcription; addition of SL1 to the extracts raises the level of Pol I transcription. These data suggest that TAF(I)41 is integral to transcriptionally active SL1 and imply a role for SL1, including the TAF(I)41 subunit, in Pol I recruitment and, therefore, preinitiation complex formation in vivo."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601601"xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601601"xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Kasciukovic T."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Kasciukovic T."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Pathak S."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Pathak S."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Russell J."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Russell J."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Gorski J.J."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Gorski J.J."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Panov K."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Panov K."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Zomerdijk J.C.B.M."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Zomerdijk J.C.B.M."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Panova T."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/author | "Panova T."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/pages | "1560-1568"xsd:string |
| http://purl.uniprot.org/citations/17318177 | http://purl.uniprot.org/core/pages | "1560-1568"xsd:string |