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| http://purl.uniprot.org/citations/17321546 | http://www.w3.org/2000/01/rdf-schema#comment | "Crystal structures of the 50 S ribosomal subunit from Haloarcula marismortui complexed with two antibiotics have identified new sites at which antibiotics interact with the ribosome and inhibit protein synthesis. 13-Deoxytedanolide binds to the E site of the 50 S subunit at the same location as the CCA of tRNA, and thus appears to inhibit protein synthesis by competing with deacylated tRNAs for E site binding. Girodazole binds near the E site region, but is somewhat buried and may inhibit tRNA binding by interfering with conformational changes that occur at the E site. The specificity of 13-deoxytedanolide for eukaryotic ribosomes is explained by its extensive interactions with protein L44e, which is an E site component of archaeal and eukaryotic ribosomes, but not of eubacterial ribosomes. In addition, protein L28, which is unique to the eubacterial E site, overlaps the site occupied by 13-deoxytedanolide, precluding its binding to eubacterial ribosomes. Girodazole is specific for eukarytes and archaea because it makes interactions with L15 that are not possible in eubacteria."xsd:string |
| http://purl.uniprot.org/citations/17321546 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2007.01.081"xsd:string |
| http://purl.uniprot.org/citations/17321546 | http://purl.uniprot.org/core/author | "Steitz T.A."xsd:string |
| http://purl.uniprot.org/citations/17321546 | http://purl.uniprot.org/core/author | "Tirado-Rives J."xsd:string |
| http://purl.uniprot.org/citations/17321546 | http://purl.uniprot.org/core/author | "Blaha G."xsd:string |
| http://purl.uniprot.org/citations/17321546 | http://purl.uniprot.org/core/author | "Moore P.B."xsd:string |
| http://purl.uniprot.org/citations/17321546 | http://purl.uniprot.org/core/author | "Schroeder S.J."xsd:string |
| http://purl.uniprot.org/citations/17321546 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17321546 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/17321546 | http://purl.uniprot.org/core/pages | "1471-1479"xsd:string |
| http://purl.uniprot.org/citations/17321546 | http://purl.uniprot.org/core/title | "The structures of antibiotics bound to the E site region of the 50 S ribosomal subunit of Haloarcula marismortui: 13-deoxytedanolide and girodazole."xsd:string |
| http://purl.uniprot.org/citations/17321546 | http://purl.uniprot.org/core/volume | "367"xsd:string |
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