| http://purl.uniprot.org/citations/17322024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17322024 | http://www.w3.org/2000/01/rdf-schema#comment | "The recent discovery of zinc signals and their essential role in the redox signaling network implies that zinc homeostasis and the function of zinc-containing proteins are probably altered as a result of oxidative stress, suggesting new targets for pharmacological intervention. We hypothesized that the level of intracellular labile zinc is changed in hearts subjected to ischemia/reperfusion (I/R) and investigated whether the maintenance of myocardial zinc status protected heart functions. Using fluorescent imaging, we demonstrated decreased levels of labile zinc in the I/R hearts. Phorbol 12-myristate 13-acetate, a known trigger of zinc release, liberated zinc ions in control hearts but failed to produce any increase in zinc levels in the I/R rat hearts. Adding the zinc ionophore pyrithione at reperfusion improved myocardial recovery up to 100% and reduced the incidence of arrhythmias more than 2-fold. This effect was dose-dependent, and high concentrations of zinc were toxic. Adding membrane-impermeable zinc chloride was ineffective. Hearts from rats receiving zinc pyrithione supplements in their diet fully recovered from I/R. The recovery was associated with the prevention of degradation of the two protein kinase C isoforms, delta and epsilon, during I/R. In conclusion, our results suggest a protective role of intracellular zinc in myocardial recovery from oxidative stress imposed by I/R. The data support the potential clinical use of zinc ionophores in the settings of acute redox stress in the heart."xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://purl.org/dc/terms/identifier | "doi:10.1124/jpet.107.119644"xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://purl.uniprot.org/core/author | "Yue Y."xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://purl.uniprot.org/core/author | "Boutjdir M."xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://purl.uniprot.org/core/author | "Karagulova G."xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://purl.uniprot.org/core/author | "Korichneva I."xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://purl.uniprot.org/core/author | "Moreyra A."xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17322024 | http://purl.uniprot.org/core/name | "J Pharmacol Exp Ther"xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://purl.uniprot.org/core/pages | "517-525"xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://purl.uniprot.org/core/title | "Protective role of intracellular zinc in myocardial ischemia/reperfusion is associated with preservation of protein kinase C isoforms."xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://purl.uniprot.org/core/volume | "321"xsd:string |
| http://purl.uniprot.org/citations/17322024 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17322024 |
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