| http://purl.uniprot.org/citations/17322172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17322172 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-6 induced vascular smooth muscle cell (VSMC) motility in a dose-dependent manner. In addition, IL-6 stimulated tyrosine phosphorylation of gp130, resulting in the recruitment and activation of STAT-3. IL-6-induced VSMC motility was found to be dependent on activation of gp130/STAT-3 signaling. IL-6 also induced cyclin D1 expression in a time- and gp130/STAT-3-dependent manner in VSMCs. Suppression of cyclin D1 levels via the use of its small interfering RNA molecules inhibited IL-6-induced VSMC motility. Furthermore, balloon injury induced IL-6 expression both at mRNA and protein levels in rat carotid artery. Balloon injury also caused increased STAT-3 phosphorylation and cyclin D1 expression, leading to smooth muscle cell migration from the media to the intimal region. Blockade of gp130/STAT-3 signaling via adenovirus-mediated expression of dngp130 or dnSTAT-3 attenuated balloon injury-induced STAT-3 phosphorylation and cyclin D1 induction, resulting in reduced smooth muscle cell migration from media to intima and decreased neointima formation. Together, these observations for the first time suggest that IL-6/gp130/STAT-3 signaling plays an important role in vascular wall remodeling particularly in the settings of postangioplasty and thereby in neointima formation."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000261350.61711.9e"xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Cao H."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Wang D."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Muller-Newen G."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Rao G.N."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Karpurapu M."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Rizvi F."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Harris K.W."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Dronadula N."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Bajpai A.K."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/author | "Kundumani-Sridharan V."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/pages | "807-816"xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/title | "An essential role for gp130 in neointima formation following arterial injury."xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/17322172 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17322172 |
| http://purl.uniprot.org/citations/17322172 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17322172 |
| http://purl.uniprot.org/uniprot/P40190#attribution-499F159D30E90E22394576AFE11091CB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17322172 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZSM2-mappedCitation-17322172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17322172 |