| http://purl.uniprot.org/citations/17324378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17324378 | http://www.w3.org/2000/01/rdf-schema#comment | "Tissue acidosis is an important feature of tumor. The response of adenoid cystic carcinoma (ACC) cells to acidic solution was studied using whole-cell patch-clamp recording in the current study. An inward, amiloride-sensitive Na(+) current was identified in cultured ACC-2 cells while not in normal human salivary gland epithelial cells. Electrophysiological and pharmacological properties of the currents suggest that heteromeric acid-sensing ion channels (ASICs) containing 2a and 3 may be responsible for the proton-induced currents in the majority of ACC-2 cells. Consistent with it, analyses of RT-PCR and Western blotting demonstrated the presences of ASIC2a and 3 in ACC-2 cells. Furthermore, we observed the enhanced expression of ASIC2a and 3 in the sample of ACC tissues. These results indicate that the functional expression of ASICs is characteristic feature of ACC cells."xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.02.061"xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/author | "Gao J."xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/author | "Hu Y.J."xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/author | "Ye J.H."xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/author | "Wu Y.N."xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/author | "Zhang C.P."xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/author | "Xu T.L."xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/pages | "986-992"xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/title | "Identification of acid-sensing ion channels in adenoid cystic carcinomas."xsd:string |
| http://purl.uniprot.org/citations/17324378 | http://purl.uniprot.org/core/volume | "355"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P78348-mappedCitation-17324378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324378 |
| http://purl.uniprot.org/uniprot/P78348 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17324378 |
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