| http://purl.uniprot.org/citations/17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17324966 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveTo test whether HLA-DR alleles influence the production of particular autoantibodies in rheumatoid arthritis (RA) patients, we screened synovial proteins with sera of RA patients homozygous for different HLA-DR alleles by using 2D blots. We found that sera of RA patients homozygous for HLA-DRB1*0404 recognised a 100-kDa synovial protein identified as calpastatin. We studied B and T cell epitopes on calpastatin and their association with HLA-DRB1*0404.MethodsThe frequency of positive sera in patients expressing different RA-associated HLA-DR allele combinations was calculated by inhouse ELISA using purified synovial calpastatin or calpastatin peptides encompassing the entire calpastatin protein as immunosorbent. Interaction between calpastatin peptides and HLA-DR alleles was tested by a direct binding assay. T cell responses to calpastatin were measured in RA patients and controls.ResultsWe found that RA-associated HLA-DR alleles are associated with presence of autoantibodies to synovial calpastatin in RA patients' sera. HLA-DRB1*0404 is strongly associated with antisynovial calpastatin in RA sera. One linear B cell epitope is preferentially associated with HLA-DRB1*0404. Multiple peptides from calpastatin bind every tested HLA-DR allele associated or not with RA. Peptides from domain 1 and 4 of calpastatin are the best HLA-DR allele binders. The T cell response to calpastatin is frequent in RA patients and independent of the HLA-DR background.ConclusionsHLA-DRB1*0404 is strongly associated with anticalpastatin antibodies in rheumatoid arthritis."xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://purl.org/dc/terms/identifier | "doi:10.1136/ard.2006.067231"xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://purl.uniprot.org/core/author | "Roudier J."xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://purl.uniprot.org/core/author | "Roudier C."xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://purl.uniprot.org/core/author | "Guis S."xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://purl.uniprot.org/core/author | "Balandraud N."xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://purl.uniprot.org/core/author | "Auger I."xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17324966 | http://purl.uniprot.org/core/name | "Ann Rheum Dis"xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://purl.uniprot.org/core/pages | "1588-1593"xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://purl.uniprot.org/core/title | "HLA-DRB1*0404 is strongly associated with anticalpastatin antibodies in rheumatoid arthritis."xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/17324966 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17324966 |
| http://purl.uniprot.org/citations/17324966 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17324966 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324966 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324966 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324966 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324966 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD60-mappedCitation-17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324966 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DD66-mappedCitation-17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324966 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI1-mappedCitation-17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324966 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI3-mappedCitation-17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324966 |
| http://purl.uniprot.org/uniprot/#_A0A141AZI4-mappedCitation-17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324966 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WAE5-mappedCitation-17324966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17324966 |