| http://purl.uniprot.org/citations/17325034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17325034 | http://www.w3.org/2000/01/rdf-schema#comment | "Herein, we report the first evidence that c-SRC is required for retinoic acid (RA) receptor (RAR) signaling, an observation that suggests a new paradigm for this family of nuclear hormone receptors. We observed that CSK negatively regulates RAR functions required for neuritogenic differentiation. CSK overexpression inhibited RA-mediated neurite outgrowth, a result which correlated with the inhibition of the SFK c-SRC. Consistent with an extranuclear effect of CSK on RAR signaling and neurite outgrowth, CSK overexpression blocked the downstream activation of RAC1. The conversion of GDP-RAC1 to GTP-RAC1 parallels the activation of c-SRC as early as 15 min following all-trans-retinoic acid treatment in LA-N-5 cells. The cytoplasmic colocalization of c-SRC and RARgamma was confirmed by immunofluorescence staining and confocal microscopy. A direct and ligand-dependent binding of RAR with SRC was observed by surface plasmon resonance, and coimmunoprecipitation studies confirmed the in vivo binding of RARgamma to c-SRC. Deletion of a proline-rich domain within RARgamma abrogated this interaction in vivo. CSK blocked the RAR-RA-dependent activation of SRC and neurite outgrowth in LA-N-5 cells. The results suggest that transcriptional signaling events mediated by RA-RAR are necessary but not sufficient to mediate complex differentiation in neuronal cells. We have elucidated a nongenomic extranuclear signal mediated by the RAR-SRC interaction that is negatively regulated by CSK and is required for RA-induced neuronal differentiation."xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01352-06"xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/author | "De P.K."xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/author | "Dey N."xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/author | "Durden D.L."xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/author | "Robertson K.A."xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/author | "Dobrota E.A."xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/pages | "4179-4197"xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/title | "CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation."xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17325034 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17325034 |
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