| http://purl.uniprot.org/citations/17327275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17327275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17327275 | http://www.w3.org/2000/01/rdf-schema#comment | "Necrotic cell death is a common feature in numerous human neurodegenerative disorders. In the nematode Caenorhabditis elegans, gain-of-function mutations in genes that encode specific ion channel subunits such as the degenerins DEG-1 and MEC-4, and the acetylcholine receptor subunit DEG-3 lead to necrotic-like degeneration of a subset of neurons. Neuronal demise caused by ion channel hyperactivity is accompanied by intense degradation of cytoplasmic contents, dramatic membrane infolding and vacuole formation; however, the cellular pathways underlying such processes remain largely unknown. Here we show that the function of three autophagy genes, whose yeast and mammalian orthologs are implicated in cytoplasmic self-degradation, membrane trafficking and the cellular response to starvation, contributes to ion-channel-dependent neurotoxicity in C. elegans. Inactivation of unc-51, bec-1 and lgg-1, the worm counterparts of the yeast autophagy genes Atg1, Atg6 and Atg8 respectively, partially suppresses degeneration of neurons with toxic ion channel variants. We also demonstrate that the TOR-kinase-mediated signaling pathway, a nutrient sensing system that downregulates the autophagy gene cascade, protects neurons from undergoing necrotic cell death, whereas nutrient deprivation promotes necrosis. Our findings reveal a role for autophagy genes in neuronal cell loss in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.03401"xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.03401"xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/author | "Simon P."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/author | "Simon P."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/author | "Vellai T."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/author | "Vellai T."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/author | "Kovacs A.L."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/author | "Kovacs A.L."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/author | "Toth M.L."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/author | "Toth M.L."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/pages | "1134-1141"xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/pages | "1134-1141"xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/title | "Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/title | "Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://purl.uniprot.org/core/volume | "120"xsd:string |
| http://purl.uniprot.org/citations/17327275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17327275 |
| http://purl.uniprot.org/citations/17327275 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17327275 |