| http://purl.uniprot.org/citations/17327452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17327452 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that interleukin (IL)-4 treatment of nonobese diabetic (NOD) mice elevates intrapancreatic CCL4 expression and protects from type 1 diabetes. Here, we show that antibody neutralization of CCL4 abrogates the ability of T-cells from IL-4-treated NOD mice to transfer protection against type 1 diabetes. Intradermal delivery of CCL4 via a plasmid vector stabilized by incorporation of the Epstein-Barr virus EBNA1/oriP episomal maintenance replicon (pHERO8100-CCL4) to NOD mice beginning at later stages of disease progression protects against type 1 diabetes. This protection was associated with a Th2-like response in the spleen and pancreas; decreased recruitment of activated CD8(+) T-cells to islets, accompanied by diminished CCR5 expression on CD8(+) T-cells; and regulatory T-cell activity in the draining pancreatic lymph nodes. Thus, inflammatory responses that target islet beta-cells are suppressed by CCL4, which implicates the use of CCL4 therapeutically to prevent type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.org/dc/terms/identifier | "doi:10.2337/db06-0619"xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/author | "Peters A."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/author | "Santamaria P."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/author | "Dekaban G.A."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/author | "Strathdee C.A."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/author | "Delovitch T.L."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/author | "Meagher C."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/author | "Mi Q.S."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/author | "Arreaza G."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/author | "Gilbert P.A."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/pages | "809-817"xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/title | "CCL4 protects from type 1 diabetes by altering islet beta-cell-targeted inflammatory responses."xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/17327452 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17327452 |
| http://purl.uniprot.org/citations/17327452 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17327452 |
| http://purl.uniprot.org/uniprot/#_P14097-mappedCitation-17327452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17327452 |
| http://purl.uniprot.org/uniprot/#_Q5QNV9-mappedCitation-17327452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17327452 |
| http://purl.uniprot.org/uniprot/P14097 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17327452 |
| http://purl.uniprot.org/uniprot/Q5QNV9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17327452 |