| http://purl.uniprot.org/citations/17329207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17329207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17329207 | http://www.w3.org/2000/01/rdf-schema#comment | "Kv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory I(Ks) current and the neuronal M-current. The five Kv7 subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain Tail. Here, we present the high-resolution structure of the Kv7.4 A-domain Tail together with biochemical experiments that show that the domain is a self-assembling, parallel, four-stranded coiled coil. Structural analysis and biochemical studies indicate conservation of the coiled coil in all Kv7 subtypes and that a limited set of interactions encode assembly specificity determinants. Kv7 mutations have prominent roles in arrhythmias, deafness, and epilepsy. The structure together with biochemical data indicate that A-domain Tail arrhythmia mutations cluster on the solvent-accessible surface of the subunit interface at a likely site of action for modulatory proteins. Together, the data provide a framework for understanding Kv7 assembly specificity and the molecular basis of a distinct set of Kv7 channelopathies."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2007.02.010"xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2007.02.010"xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/author | "Holton J.M."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/author | "Holton J.M."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/author | "Howard R.J."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/author | "Howard R.J."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/author | "Minor D.L. Jr."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/author | "Minor D.L. Jr."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/author | "Clark K.A."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/author | "Clark K.A."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/pages | "663-675"xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/pages | "663-675"xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/title | "Structural insight into KCNQ (Kv7) channel assembly and channelopathy."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/title | "Structural insight into KCNQ (Kv7) channel assembly and channelopathy."xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://purl.uniprot.org/core/volume | "53"xsd:string |
| http://purl.uniprot.org/citations/17329207 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17329207 |
| http://purl.uniprot.org/citations/17329207 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17329207 |