| http://purl.uniprot.org/citations/17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17330803 | http://www.w3.org/2000/01/rdf-schema#comment | "Fetal breathing-like movements (FBMs) are important in normal lung growth and pneumocyte differentiation. In amyogenic mouse embryos (designated as Myf5-/-:MyoD-/-, entirely lacking skeletal musculature and FBMs), type II pneumocytes fail to differentiate into type I pneumocytes, the cells responsible for gas exchange, and the fetuses die from asphyxia at birth. Using oligonucleotide microarrays, we compared gene expression in the lungs of Myf5-/-:MyoD-/-embryos to that in normal lungs at term. Nine genes were found to be up-regulated and 54 down-regulated at least 2-fold in the lungs of double-mutant embryos. Since many down-regulated genes are involved in lymphocyte function, immunohistochemistry was employed to study T- and B-cell maturity in the thymus and spleen. Our findings of normal lymphocyte maturity implied that the down-regulation was specific to the double-mutant lung phenotype and not to its immune system. Immunostaining also revealed altered distribution of transcription and growth factors (SATB1, c-Myb, CTGF) from down-regulated genes whose knockouts are now known to undergo embryonic or neonatal death secondary to respiratory failure. Together, it appears that microarray analysis has identified a profile of genes potentially involved in pneumocyte differentiation and therefore in the mechanisms that may be implicated in the mechanochemical signal transduction pathways underlying FBMs-dependent pulmonary hypoplasia."xsd:string |
| http://purl.uniprot.org/citations/17330803 | http://purl.org/dc/terms/identifier | "doi:10.14670/hh-22.483"xsd:string |
| http://purl.uniprot.org/citations/17330803 | http://purl.uniprot.org/core/author | "Kablar B."xsd:string |
| http://purl.uniprot.org/citations/17330803 | http://purl.uniprot.org/core/author | "Baguma-Nibasheka M."xsd:string |
| http://purl.uniprot.org/citations/17330803 | http://purl.uniprot.org/core/author | "Inanlou M.R."xsd:string |
| http://purl.uniprot.org/citations/17330803 | http://purl.uniprot.org/core/author | "Angka H.E."xsd:string |
| http://purl.uniprot.org/citations/17330803 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17330803 | http://purl.uniprot.org/core/name | "Histol Histopathol"xsd:string |
| http://purl.uniprot.org/citations/17330803 | http://purl.uniprot.org/core/pages | "483-495"xsd:string |
| http://purl.uniprot.org/citations/17330803 | http://purl.uniprot.org/core/title | "Microarray analysis of Myf5-/-:MyoD-/- hypoplastic mouse lungs reveals a profile of genes involved in pneumocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/17330803 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/17330803 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17330803 |
| http://purl.uniprot.org/citations/17330803 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17330803 |
| http://purl.uniprot.org/uniprot/#_A0A087WPA7-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |
| http://purl.uniprot.org/uniprot/#_A0A075B5J5-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |
| http://purl.uniprot.org/uniprot/#_E0CXP3-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |
| http://purl.uniprot.org/uniprot/#_E9Q0S5-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |
| http://purl.uniprot.org/uniprot/#_A2NU22-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |
| http://purl.uniprot.org/uniprot/#_A0A140T8L9-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |
| http://purl.uniprot.org/uniprot/#_A2A4K2-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |
| http://purl.uniprot.org/uniprot/#_A6H6M1-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |
| http://purl.uniprot.org/uniprot/#_A2RSK4-mappedCitation-17330803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17330803 |