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http://purl.uniprot.org/citations/17331366http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17331366http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To clarify expression and subcellular localization of XIAP and XAF1 protein in human normal oral keratinocytes (hNOK) and Tca8113 cells human tongue carcinoma cell line.

Methods

The hNOKs and Tca8113 cells were cultured in vitro. Expression and subcellular localization of XIAP and XAF1 protein were examined by combination of indirect immunofluorescence and confocal laser scanning microscopy.

Results

XIAP expression was weak in the hNOKs and fluorescence staining localized chiefly in the cytoplasm and perinuclear areas. In the Tca8113 cells, high level of XIAP protein could be detected in both the cytoplasm and the nucleus. In the hNOKs, XAF1 distributed mostly in the nucleus. Homogeneous nuclear and cytoplasmic distribution of XAF1 could be visualized in the Tca8113 cells.

Conclusions

In cancerization of oral mucosa, XIAP protein could play an important antiapoptotic role by overexpression, while XAF1 protein does not appear to antagonize effectively the role of XIAP."xsd:string
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/author"Wei X.F."xsd:string
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/author"Chen Y.X."xsd:string
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/author"Zhu L.K."xsd:string
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/author"Gao W.X."xsd:string
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/name"Zhonghua Kou Qiang Yi Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/pages"682-683"xsd:string
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/title"[Expression and subcellular localization of XIAP and XAF1 in human normal oral keratinocytes and Tca8113 cells]."xsd:string
http://purl.uniprot.org/citations/17331366http://purl.uniprot.org/core/volume"41"xsd:string
http://purl.uniprot.org/citations/17331366http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17331366
http://purl.uniprot.org/citations/17331366http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17331366
http://purl.uniprot.org/uniprot/#_B2R9R2-mappedCitation-17331366http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17331366
http://purl.uniprot.org/uniprot/#_B3KPW1-mappedCitation-17331366http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17331366
http://purl.uniprot.org/uniprot/#_P98170-mappedCitation-17331366http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17331366
http://purl.uniprot.org/uniprot/#_Q6GPH4-mappedCitation-17331366http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17331366
http://purl.uniprot.org/uniprot/B3KPW1http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17331366
http://purl.uniprot.org/uniprot/P98170http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17331366
http://purl.uniprot.org/uniprot/Q6GPH4http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17331366
http://purl.uniprot.org/uniprot/B2R9R2http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17331366