| http://purl.uniprot.org/citations/17331723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17331723 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hedgehog (Hh) and Wingless (Wnt) families of secreted signaling molecules have key roles in embryonic development and adult tissue homeostasis [1-3]. In the developing neural tube, Wnt and Shh, emanating from dorsal and ventral regions, respectively, have been proposed to govern the proliferation and survival of neural progenitors [4-10]. Surprisingly, Shh is required for the growth and survival of cells in both ventral and dorsal neural tube [11]. Here we demonstrate that inhibition of Shh signaling causes a reduction in Wnt-mediated transcriptional activation. This reduction requires Gli3. Assays in embryos and cell lines indicate that repressor forms of the Hh-regulated transcription factor, Gli3 (Gli3R), which are generated in the absence of Hh signaling, inhibit canonical Wnt signaling. Gli3R acts by antagonizing active forms of the Wnt transcriptional effector, beta-catenin. Consistent with this, Gli3R appears to physically interact with the carboxy-terminal domain of beta-catenin, a region that includes the transactivation domain. These data offer an explanation for the proliferative defects in Shh null embryos and suggest a novel mechanism for crosstalk between the Hh and Wnt pathways."xsd:string |
| http://purl.uniprot.org/citations/17331723 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2007.01.062"xsd:string |
| http://purl.uniprot.org/citations/17331723 | http://purl.uniprot.org/core/author | "Ulloa F."xsd:string |
| http://purl.uniprot.org/citations/17331723 | http://purl.uniprot.org/core/author | "Briscoe J."xsd:string |
| http://purl.uniprot.org/citations/17331723 | http://purl.uniprot.org/core/author | "Itasaki N."xsd:string |
| http://purl.uniprot.org/citations/17331723 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17331723 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/17331723 | http://purl.uniprot.org/core/pages | "545-550"xsd:string |
| http://purl.uniprot.org/citations/17331723 | http://purl.uniprot.org/core/title | "Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/17331723 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/17331723 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17331723 |
| http://purl.uniprot.org/citations/17331723 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17331723 |
| http://purl.uniprot.org/uniprot/Q02248#attribution-14F13A34425B1279686E59916D195E0A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17331723 |
| http://purl.uniprot.org/uniprot/P10071#attribution-04146265CDA6165D6844976B97647F5B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17331723 |
| http://purl.uniprot.org/uniprot/P10071#attribution-14F13A34425B1279686E59916D195E0A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17331723 |
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| http://purl.uniprot.org/uniprot/#_A2ABQ9-mappedCitation-17331723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17331723 |