| http://purl.uniprot.org/citations/17332504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17332504 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17332504 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor suppressor p53 is a key transcriptional factor regulating the induction of cellular senescence by oncogenic signals. The activity of p53 is regulated by recruitment into promyelocytic leukemia (PML)-nuclear bodies (NBs) as well as by stabilization through posttranslational modifications such as phosphorylation and acetylation. Here we found that MORC3 (microrchidia3)-ATPase activated p53 and induced cellular senescence in normal human and mouse fibroblasts but not p53-/-fibroblasts. Conversely, genotoxic stress-induced phosphorylation and stabilization of p53 but barely increased its transcriptional activity in Morc3-/-fibroblasts. MORC3 localized on PML-NBs in presence of PML and mediated recruitment of p53 and CREB-binding protein (CBP) into PML-NBs. In contrast, expression of ATPase activity-deficient mutant MORC3-E35A or siRNA repression of MORC3 impaired the localization of p53 and Sp100 but not CBP on PML-NBs. These results suggest that MORC3 regulates p53 activity and localization into PML-NBs. We identified a new molecular mechanism that regulates the activity of nuclear proteins by localization to a nuclear subdomain."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e06-08-0747"xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e06-08-0747"xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Inoue N."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Inoue N."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Yoshida N."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Yoshida N."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Zinn A.R."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Zinn A.R."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Ishizaki H."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Ishizaki H."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Miyoshi J."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Miyoshi J."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Murakami N."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Murakami N."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Shime H."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Shime H."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Kawata K."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Kawata K."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Tanaka-Okamoto M."xsd:string |
| http://purl.uniprot.org/citations/17332504 | http://purl.uniprot.org/core/author | "Tanaka-Okamoto M."xsd:string |