| http://purl.uniprot.org/citations/17332754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17332754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17332754 | http://www.w3.org/2000/01/rdf-schema#comment | "Alcadeinalpha (Alcalpha) is an evolutionarily conserved type I membrane protein expressed in neurons. We show here that Alcalpha strongly associates with kinesin light chain (K(D) approximately 4-8x10(-9) M) through a novel tryptophan- and aspartic acid-containing sequence. Alcalpha can induce kinesin-1 association with vesicles and functions as a novel cargo in axonal anterograde transport. JNK-interacting protein 1 (JIP1), an adaptor protein for kinesin-1, perturbs the transport of Alcalpha, and the kinesin-1 motor complex dissociates from Alcalpha-containing vesicles in a JIP1 concentration-dependent manner. Alcalpha-containing vesicles were transported with a velocity different from that of amyloid beta-protein precursor (APP)-containing vesicles, which are transported by the same kinesin-1 motor. Alcalpha- and APP-containing vesicles comprised mostly separate populations in axons in vivo. Interactions of Alcalpha with kinesin-1 blocked transport of APP-containing vesicles and increased beta-amyloid generation. Inappropriate interactions of Alc- and APP-containing vesicles with kinesin-1 may promote aberrant APP metabolism in Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601609"xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601609"xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Kobayashi H."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Kobayashi H."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Kawano T."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Kawano T."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Miyamoto K."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Miyamoto K."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Saito Y."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Yamamoto T."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Araki Y."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Araki Y."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Taru H."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Taru H."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Wada S."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Wada S."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Matsuno K."xsd:string |
| http://purl.uniprot.org/citations/17332754 | http://purl.uniprot.org/core/author | "Matsuno K."xsd:string |