| http://purl.uniprot.org/citations/17334233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17334233 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of matrix metalloproteinase-9 (MMP-9) is associated with airway remodeling and tissue injury in asthma. However, little is known about how MMP-9 is up-regulated in airway epithelial cells. In this study, we show that phorbol myristate acetate (PMA) induces MMP-9 expression via a protein kinase Calpha (PKCalpha)-dependent signaling cascade in BEAS-2B human lung epithelial cells. Pretreatment with either GF109203X, a general PKC inhibitor, or Go6976, a PKCalpha/beta isozyme inhibitor, inhibited PMA-induced activation of the MMP-9 promoter, as did transient transfection with PKCalpha antisense oligonuclotides. PMA activated NF-kappaB by phosphorylating IkappaB in these cells and this was also inhibited by GF109203X and Go6976, suggesting that PKCa acts as an upstream regulator of NF-kappaB in PMA-induced MMP-9 induction. Our results indicate that a "PKCalpha-NF-kappaB"-dependent cascade is involved in the signaling leading to PMA-induced MMP-9 expression in the lung epithelium."xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.org/dc/terms/identifier | "doi:10.1038/emm.2007.11"xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/author | "Yoon S.H."xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/author | "Shin Y."xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/author | "Cho S.H."xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/author | "Choe E.Y."xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/author | "Woo C.H."xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/author | "Rho J.Y."xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/name | "Exp Mol Med"xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/pages | "97-105"xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/title | "PMA-induced up-regulation of MMP-9 is regulated by a PKCalpha-NF-kappaB cascade in human lung epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/17334233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17334233 |
| http://purl.uniprot.org/citations/17334233 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17334233 |
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