| http://purl.uniprot.org/citations/17334360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17334360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17334360 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal development, plasticity and survival require activity-dependent synapse-to-nucleus signaling. Most studies implicate an activity-dependent regulation of gene expression in this phenomenon. However, little is known about other nuclear functions that are regulated by synaptic activity. Here we show that a newly identified component of rat postsynaptic densities (PSDs), AIDA-1d, can regulate global protein synthesis by altering nucleolar numbers. AIDA-1d binds to the first two postsynaptic density-95/Discs large/zona occludens-1 (PDZ) domains of the scaffolding protein PSD-95 via its C-terminal three amino acids. Stimulation of NMDA receptors (NMDARs), which are also bound to PSD-95, results in a Ca2+-independent translocation of AIDA-1d to the nucleus, where it couples to Cajal bodies and induces Cajal body-nucleolar association. Long-term neuronal stimulation results in an AIDA-1-dependent increase in nucleolar numbers and protein synthesis. We propose that AIDA-1d mediates a link between synaptic activity and control of protein biosynthetic capacity by regulating nucleolar assembly."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn1867"xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn1867"xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/author | "Fernholz B.D."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/author | "Fernholz B.D."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/author | "Jordan B.A."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/author | "Jordan B.A."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/author | "Khatri L."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/author | "Khatri L."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/author | "Ziff E.B."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/author | "Ziff E.B."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/name | "Nat. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/name | "Nat. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/pages | "427-435"xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/pages | "427-435"xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/title | "Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/title | "Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons."xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/17334360 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17334360 |
| http://purl.uniprot.org/citations/17334360 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17334360 |