| http://purl.uniprot.org/citations/17334366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17334366 | http://www.w3.org/2000/01/rdf-schema#comment | "Whether mitochondrial mutations cause mammalian aging, or are merely correlated with it, is an area of intense debate. Here, we use a new, highly sensitive assay to redefine the relationship between mitochondrial mutations and age. We measured the in vivo rate of change of the mitochondrial genome at a single-base pair level in mice, and we demonstrate that the mutation frequency in mouse mitochondria is more than ten times lower than previously reported. Although we observed an 11-fold increase in mitochondrial point mutations with age, we report that a mitochondrial mutator mouse was able to sustain a 500-fold higher mutation burden than normal mice, without any obvious features of rapidly accelerated aging. Thus, our results strongly indicate that mitochondrial mutations do not limit the lifespan of wild-type mice."xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1988"xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/author | "Prolla T.A."xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/author | "Loeb L.A."xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/author | "Bielas J.H."xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/author | "Rabinovitch P.S."xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/author | "Ladiges W.C."xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/author | "Kujoth G.C."xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/author | "Vermulst M."xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/pages | "540-543"xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/title | "Mitochondrial point mutations do not limit the natural lifespan of mice."xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/17334366 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17334366 |
| http://purl.uniprot.org/citations/17334366 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17334366 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTR4-mappedCitation-17334366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17334366 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTZ6-mappedCitation-17334366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17334366 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU03-mappedCitation-17334366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17334366 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU70-mappedCitation-17334366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17334366 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUA1-mappedCitation-17334366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17334366 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV64-mappedCitation-17334366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17334366 |
| http://purl.uniprot.org/uniprot/#_P54099-mappedCitation-17334366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17334366 |
| http://purl.uniprot.org/uniprot/#_F6YLN2-mappedCitation-17334366 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17334366 |