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http://purl.uniprot.org/citations/17334369http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17334369http://www.w3.org/2000/01/rdf-schema#comment"Lymphocyte homing is mediated by specific interaction between L-selectin on lymphocytes and the carbohydrate ligand 6-sulfo sialyl Lewis X on high endothelial venules. Here we generated mice lacking both core 1 extension and core 2 branching enzymes to assess the functions of O-glycan-borne L-selectin ligands in vivo. Mutant mice maintained robust lymphocyte homing, yet they lacked O-glycan L-selectin ligands. Biochemical analyses identified a class of N-glycans bearing the 6-sulfo sialyl Lewis X L-selectin ligand in high endothelial venules. These N-glycans supported the binding of L-selectin to high endothelial venules in vitro and contributed in vivo to O-glycan-independent lymphocyte homing in wild-type and mutant mice. Our results demonstrate the critical function of N-glycan-linked 6-sulfo sialyl Lewis X in L-selectin-dependent lymphocyte homing and recruitment."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.org/dc/terms/identifier"doi:10.1038/ni1442"xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Fukuda M."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Saito H."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Ohtsubo K."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Bao X."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Khoo K.H."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Kawashima H."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Lowe J.B."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Marth J.D."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Gauguet J.M."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Mitoma J."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Yu S.Y."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"von Andrian U.H."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Schaerli P."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/author"Petryanik B."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/name"Nat Immunol"xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/pages"409-418"xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/title"Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment."xsd:string
http://purl.uniprot.org/citations/17334369http://purl.uniprot.org/core/volume"8"xsd:string
http://purl.uniprot.org/citations/17334369http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17334369
http://purl.uniprot.org/citations/17334369http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17334369
http://purl.uniprot.org/uniprot/#_Q09324-mappedCitation-17334369http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17334369