| http://purl.uniprot.org/citations/17335351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17335351 | http://www.w3.org/2000/01/rdf-schema#comment | "Ectotherms rely for their body heat on surrounding temperatures. A key question in biology is why most ectotherms mature at a larger size at lower temperatures, a phenomenon known as the temperature-size rule. Since temperature affects virtually all processes in a living organism, current theories to explain this phenomenon are diverse and complex and assert often from opposing assumptions. Although widely studied, the molecular genetic control of the temperature-size rule is unknown. We found that the Caenorhabditis elegans wild-type N2 complied with the temperature-size rule, whereas wild-type CB4856 defied it. Using a candidate gene approach based on an N2 x CB4856 recombinant inbred panel in combination with mutant analysis, complementation, and transgenic studies, we show that a single nucleotide polymorphism in tra-3 leads to mutation F96L in the encoded calpain-like protease. This mutation attenuates the ability of CB4856 to grow larger at low temperature. Homology modelling predicts that F96L reduces TRA-3 activity by destabilizing the DII-A domain. The data show that size adaptation of ectotherms to temperature changes may be less complex than previously thought because a subtle wild-type polymorphism modulates the temperature responsiveness of body size. These findings provide a novel step toward the molecular understanding of the temperature-size rule, which has puzzled biologists for decades."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.0030034"xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/author | "Plasterk R.H."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/author | "Tijsterman M."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/author | "Bakker J."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/author | "Kammenga J.E."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/author | "Hazendonk E."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/author | "Doroszuk A."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/author | "Petrescu A.J."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/author | "Spiridon L."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/author | "Riksen J.A."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/pages | "e34"xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/title | "A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide polymorphism in tra-3."xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/17335351 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17335351 |
| http://purl.uniprot.org/citations/17335351 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17335351 |
| http://purl.uniprot.org/uniprot/#_Q22036-mappedCitation-17335351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17335351 |
| http://purl.uniprot.org/uniprot/Q22036 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17335351 |