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| http://purl.uniprot.org/citations/17336904 | http://www.w3.org/2000/01/rdf-schema#comment | "Chondrocyte hypertrophy is essential for endochondral bone development. Unexpectedly, we discovered that MEF2C, a transcription factor that regulates muscle and cardiovascular development, controls bone development by activating the gene program for chondrocyte hypertrophy. Genetic deletion of Mef2c or expression of a dominant-negative MEF2C mutant in endochondral cartilage impairs hypertrophy, cartilage angiogenesis, ossification, and longitudinal bone growth in mice. Conversely, a superactivating form of MEF2C causes precocious chondrocyte hypertrophy, ossification of growth plates, and dwarfism. Endochondral bone formation is exquisitely sensitive to the balance between MEF2C and the corepressor histone deacetylase 4 (HDAC4), such that bone deficiency of Mef2c mutant mice can be rescued by an Hdac4 mutation, and ectopic ossification in Hdac4 null mice can be diminished by a heterozygous Mef2c mutation. These findings reveal unexpected commonalities in the mechanisms governing muscle, cardiovascular, and bone development with respect to their regulation by MEF2 and class II HDACs."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2007.02.004"xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/author | "Kim Y."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/author | "Bassel-Duby R."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/author | "Richardson J.A."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/author | "Shelton J.M."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/author | "Arnold M.A."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/author | "Phan D."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/author | "McAnally J."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/author | "Czubryt M.P."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/pages | "377-389"xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/title | "MEF2C transcription factor controls chondrocyte hypertrophy and bone development."xsd:string |
| http://purl.uniprot.org/citations/17336904 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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