| http://purl.uniprot.org/citations/17339230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17339230 | http://www.w3.org/2000/01/rdf-schema#comment | "c-Abl non-receptor tyrosine kinase has been implicated in many cellular processes including cell differentiation, stress response and regulating gene transcription. The mechanism by which c-Abl is involved in the regulation of gene transcription remains to be elucidated. In this study, we investigated the functions of c-Abl in the activation of p21 promoter. Our results showed that overexpression of c-Abl tyrosine kinase activated p21 promoter and endogenous p21 transcription in U2OS cells. We found that p53 is involved in the activation of p21 promoter by c-Abl, and integrative structure of p53 is required for regulating p21 transcription. In addition, the chromatin immunoprecipitation study demonstrated that c-Abl and p53 can be recruited to the region containing p53 binding site of p21 promoter, and c-Abl increases the DNA binding activity of p53 to the p21 promoter. Furthermore, not only the activation of p21 promoter but also the recruitment to p21 promoter by c-Abl is dependent on the interaction between c-Abl and p53 protein."xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.org/dc/terms/identifier | "doi:10.1093/jb/mvm068"xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/author | "Gu C."xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/author | "Tang W."xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/author | "Qi T."xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/author | "Zeng X."xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/author | "Jing Y."xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/author | "Hao S."xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/name | "J Biochem"xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/pages | "621-626"xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/title | "c-Abl tyrosine kinase activates p21 transcription via interaction with p53."xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/17339230 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17339230 |
| http://purl.uniprot.org/citations/17339230 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17339230 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-17339230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17339230 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-17339230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17339230 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-17339230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17339230 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-17339230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17339230 |
| http://purl.uniprot.org/uniprot/#_A0A023PX70-mappedCitation-17339230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17339230 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-17339230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17339230 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-17339230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17339230 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-17339230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17339230 |