| http://purl.uniprot.org/citations/17339378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17339378 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell death during Drosophila melanogaster metamorphosis is controlled by the steroid hormone 20-hydroxyecdysone (20E). Elements of the signaling pathway that triggers death are known, but it is not known why some tissues, and not others, die in response to a particular hormone pulse. We found that loss of the tissue-specific transcription factor Fork head (Fkh) is both required and sufficient to specify a death response to 20E in the larval salivary glands. Loss of fkh itself is a steroid-controlled event that is mediated by the 20E-induced BR-C gene, and that renders the key death regulators hid and reaper hormone responsive. These results implicate the D. melanogaster FOXA orthologue Fkh with a novel function as a competence factor for steroid-controlled cell death. They explain how a specific tissue is singled out for death, and why this tissue survives earlier hormone pulses. More generally, they suggest that cell identity factors like Fkh play a pivotal role in the normal control of developmental cell death."xsd:string |
| http://purl.uniprot.org/citations/17339378 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200611155"xsd:string |
| http://purl.uniprot.org/citations/17339378 | http://purl.uniprot.org/core/author | "Cao C."xsd:string |
| http://purl.uniprot.org/citations/17339378 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/17339378 | http://purl.uniprot.org/core/author | "Lehmann M."xsd:string |
| http://purl.uniprot.org/citations/17339378 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17339378 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17339378 | http://purl.uniprot.org/core/pages | "843-852"xsd:string |
| http://purl.uniprot.org/citations/17339378 | http://purl.uniprot.org/core/title | "Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death."xsd:string |
| http://purl.uniprot.org/citations/17339378 | http://purl.uniprot.org/core/volume | "176"xsd:string |
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