| http://purl.uniprot.org/citations/17339379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17339379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17339379 | http://www.w3.org/2000/01/rdf-schema#comment | "Nucleosomes containing the centromere-specific histone H3 variant centromere protein A (CENP-A) create the chromatin foundation for kinetochore assembly. To understand the mechanisms that selectively target CENP-A to centromeres, we took a functional genomics approach in the nematode Caenorhabditis elegans, in which failure to load CENP-A results in a signature kinetochore-null (KNL) phenotype. We identified a single protein, KNL-2, that is specifically required for CENP-A incorporation into chromatin. KNL-2 and CENP-A localize to centromeres throughout the cell cycle in an interdependent manner and coordinately direct chromosome condensation, kinetochore assembly, and chromosome segregation. The isolation of KNL-2-associated chromatin coenriched CENP-A, indicating their close proximity on DNA. KNL-2 defines a new conserved family of Myb DNA-binding domain-containing proteins. The human homologue of KNL-2 is also specifically required for CENP-A loading and kinetochore assembly but is only transiently present at centromeres after mitotic exit. These results implicate a new protein class in the assembly of centromeric chromatin and suggest that holocentric and monocentric chromosomes share a common mechanism for CENP-A loading."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200701065"xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200701065"xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/author | "Desai A."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/author | "Desai A."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/author | "Oegema K."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/author | "Oegema K."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/author | "Maddox P.S."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/author | "Maddox P.S."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/author | "Hyndman F."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/author | "Hyndman F."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/author | "Monen J."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/author | "Monen J."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/pages | "757-763"xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/pages | "757-763"xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/title | "Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/title | "Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin."xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/17339379 | http://purl.uniprot.org/core/volume | "176"xsd:string |