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http://purl.uniprot.org/citations/17343323http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17343323http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the role of ligands for programmed cell death 1 (PD-L) in the pathogenesis of systemic lupus erythematosus (SLE).

Methods

One hundred sixty-four patients with SLE and 160 healthy controls were enrolled in our study. The PD-L1 and PD-L2 polymorphisms were determined by polymerase chain reaction (PCR)/direct sequencing or restriction fragment length polymorphism (RFLP)-PCR.

Results

The genotype distributions of PD-L2 47103 C/T polymorphisms in patients with SLE were significantly different from those of the controls (p = 0.003). The genotype frequency of PD-L2 47103 T/T, in comparison with 47103 C/C, was significantly increased in patients with SLE when compared with that of the controls (odds ratio 2.5, 95% confidence interval 1.4-4.4, p = 0.001). A similar finding could also be found in the allele frequency of PD-L2 47103 T (SLE vs control, OR 1.7, 95% CI 1.3-2.4, p = 0.001). There were no significant differences in the genotype and allele frequencies of PD-L1 polymorphisms between the patients and controls.

Conclusion

PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan."xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/author"Lin C.H."xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/author"Wang S.C."xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/author"Liu H.W."xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/author"Hu C.J."xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/author"Wu C.C."xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/author"Tsai W.C."xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/author"Yen J.H."xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/author"Ou T.T."xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/name"J Rheumatol"xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/pages"721-725"xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/title"Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus."xsd:string
http://purl.uniprot.org/citations/17343323http://purl.uniprot.org/core/volume"34"xsd:string
http://purl.uniprot.org/citations/17343323http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17343323
http://purl.uniprot.org/citations/17343323http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17343323
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http://purl.uniprot.org/uniprot/A4GW21http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17343323
http://purl.uniprot.org/uniprot/Q9BQ51http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/17343323