| http://purl.uniprot.org/citations/17344420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17344420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17344420 | http://www.w3.org/2000/01/rdf-schema#comment | "Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, we demonstrate a mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathways) in the assembly of mitochondrial complex I (NADH:ubiquinone oxidoreductase). An N-terminal targeting signal directs Ecsit to mitochondria, where it interacts with assembly chaperone NDUFAF1 in 500-to 850-kDa complexes as demonstrated by affinity purification and vice versa RNA interference (RNAi) knockdowns. In addition, Ecsit knockdown results in severely impaired complex I assembly and disturbed mitochondrial function. These findings support a function for Ecsit in the assembly or stability of mitochondrial complex I, possibly linking assembly of oxidative phosphorylation complexes to inflammatory response and embryonic development."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.408407"xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.408407"xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Vogel R.O."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Vogel R.O."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Koopman W.J.H."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Koopman W.J.H."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Smeitink J.A.M."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Smeitink J.A.M."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "van den Heuvel L.P.W.J."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "van den Heuvel L.P.W.J."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Dieteren C.E.J."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Dieteren C.E.J."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Janssen R.J.R.J."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Janssen R.J.R.J."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Nijtmans L.G.J."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Nijtmans L.G.J."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Pluk W."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Pluk W."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Verkaart S."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Verkaart S."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Willems P.H.G.M."xsd:string |
| http://purl.uniprot.org/citations/17344420 | http://purl.uniprot.org/core/author | "Willems P.H.G.M."xsd:string |