| http://purl.uniprot.org/citations/17348823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17348823 | http://www.w3.org/2000/01/rdf-schema#comment | "To ascertain whether single nucleotide polymorphisms (SNPs) regulating the expression of interferon-gamma (IFN-gamma), IFN-gamma receptor-1 (IFNGR-1), interleukin-6 (IL-6), IL-10, IL-18, and tumor necrosis factor-alpha (TNF-alpha) may be associated with early fibrosis progression of recurrent hepatitis C, 50 liver transplantation recipients (32 men, 18 women, median age 56 years) with a median histologic follow-up time of 54 months were studied; 98 healthy blood donors served as controls. Cytokine SNPs were determined by means of previously described PCR-based methods. On the basis of the SNP studies, a low, intermediate, or high producer cytokine phenotype was attributed to each patient. Only 1 of the 17 low IL-10 producers reached an Ishak staging score > 2, in contrast to 20 of the 33 patients who were intermediate or high IL-10 producers (Mantel-Cox, p < 0.005). Recipients who were low IL-10 producers and high IFN-gamma producers had significantly slower fibrosis progression in comparison to intermediate/high IL-10 producers and low IFN-gamma producers (p < 0.005). In conclusion, cytokine SNPs resulting in high and low producer phenotypes of both Th1 and Th2 cytokines appear to modulate the course of recurrent hepatitis C. Low IL-10 producers are those with the slowest histologic fibrosis progression."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.org/dc/terms/identifier | "doi:10.1089/jir.2006.0062"xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Rossi E."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Fabris C."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Pirisi M."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Toniutto P."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Caldato M."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Minisini R."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Bitetto D."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Smirne C."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Cussigh A."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Falleti E."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/author | "Fontanini E."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/name | "J Interferon Cytokine Res"xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/pages | "239-246"xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/title | "Genetic polymorphisms of inflammatory cytokines and liver fibrosis progression due to recurrent hepatitis C."xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17348823 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17348823 |
| http://purl.uniprot.org/citations/17348823 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17348823 |
| http://purl.uniprot.org/uniprot/#_P15260-mappedCitation-17348823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17348823 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3Y2-mappedCitation-17348823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17348823 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3R7-mappedCitation-17348823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17348823 |
| http://purl.uniprot.org/uniprot/#_A0A2R8Y4U4-mappedCitation-17348823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17348823 |