| http://purl.uniprot.org/citations/17350258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17350258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17350258 | http://www.w3.org/2000/01/rdf-schema#comment | "A series of aryl sulfonamides of 5,6-disubstituted anthranilic acids were identified as potent inhibitors of methionine aminopeptidase-2 (MetAP2). Small alkyl groups and 3-furyl were tolerated at the 5-position of anthranilic acid, while -OCH(3), CH(3), and Cl were found optimal for the 6-position. Placement of 2-aminoethoxy group at the 6-position enabled interaction with the second Mn(2+) but did not result in enhancement in potency. Introduction of a tertiary amino moiety at the ortho-position of the sulfonyl phenyl ring gave reduced protein binding and improved cellular activity, but led to lower oral bioavailability."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2007.02.062"xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2007.02.062"xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Park C."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Park C."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Wang G.T."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Wang G.T."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Kawai M."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Kawai M."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Sheppard G.S."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Sheppard G.S."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Yates M."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Yates M."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Lesniewski R."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Lesniewski R."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Lou P."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Lou P."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Barnes D.M."xsd:string |
| http://purl.uniprot.org/citations/17350258 | http://purl.uniprot.org/core/author | "Barnes D.M."xsd:string |