| http://purl.uniprot.org/citations/17351618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17351618 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17351618 | http://www.w3.org/2000/01/rdf-schema#comment | "To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1450"xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1450"xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Hammel M."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Hammel M."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Geisbrecht B.V."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Geisbrecht B.V."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Lambris J.D."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Lambris J.D."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Magotti P."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Magotti P."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Ricklin D."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Ricklin D."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Sfyroera G."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/author | "Sfyroera G."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/pages | "430-437"xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/pages | "430-437"xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/title | "A structural basis for complement inhibition by Staphylococcus aureus."xsd:string |
| http://purl.uniprot.org/citations/17351618 | http://purl.uniprot.org/core/title | "A structural basis for complement inhibition by Staphylococcus aureus."xsd:string |