| http://purl.uniprot.org/citations/17352659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17352659 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively degrades mRNAs harboring premature termination (nonsense) codons. If translated, these mRNAs can produce truncated proteins with dominant-negative or deleterious gain-of-function activities. In this review, we describe the molecular mechanism of NMD. We first cover conserved factors known to be involved in NMD in all eukaryotes. We then describe a unique protein complex that is deposited on mammalian mRNAs during splicing, which defines a stop codon as premature. Interaction between this exon-junction complex (EJC) and NMD factors assembled at the upstream stop codon triggers a series of steps that ultimately lead to mRNA decay. We discuss whether these proofreading events preferentially occur during a "pioneer" round of translation in higher and lower eukaryotes, their cellular location, and whether they can use alternative EJC factors or act independent of the EJC."xsd:string |
| http://purl.uniprot.org/citations/17352659 | http://purl.org/dc/terms/identifier | "doi:10.1146/annurev.biochem.76.050106.093909"xsd:string |
| http://purl.uniprot.org/citations/17352659 | http://purl.uniprot.org/core/author | "Chang Y.F."xsd:string |
| http://purl.uniprot.org/citations/17352659 | http://purl.uniprot.org/core/author | "Wilkinson M.F."xsd:string |
| http://purl.uniprot.org/citations/17352659 | http://purl.uniprot.org/core/author | "Imam J.S."xsd:string |
| http://purl.uniprot.org/citations/17352659 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17352659 | http://purl.uniprot.org/core/name | "Annu Rev Biochem"xsd:string |
| http://purl.uniprot.org/citations/17352659 | http://purl.uniprot.org/core/pages | "51-74"xsd:string |
| http://purl.uniprot.org/citations/17352659 | http://purl.uniprot.org/core/title | "The nonsense-mediated decay RNA surveillance pathway."xsd:string |
| http://purl.uniprot.org/citations/17352659 | http://purl.uniprot.org/core/volume | "76"xsd:string |
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