| http://purl.uniprot.org/citations/17353931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17353931 | http://www.w3.org/2000/01/rdf-schema#comment | "Mapping protein-protein interactions is an invaluable tool for understanding protein function. Here, we report the first large-scale study of protein-protein interactions in human cells using a mass spectrometry-based approach. The study maps protein interactions for 338 bait proteins that were selected based on known or suspected disease and functional associations. Large-scale immunoprecipitation of Flag-tagged versions of these proteins followed by LC-ESI-MS/MS analysis resulted in the identification of 24,540 potential protein interactions. False positives and redundant hits were filtered out using empirical criteria and a calculated interaction confidence score, producing a data set of 6463 interactions between 2235 distinct proteins. This data set was further cross-validated using previously published and predicted human protein interactions. In-depth mining of the data set shows that it represents a valuable source of novel protein-protein interactions with relevance to human diseases. In addition, via our preliminary analysis, we report many novel protein interactions and pathway associations."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.org/dc/terms/identifier | "doi:10.1038/msb4100134"xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Sheng Y."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Taylor P."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Taylor R."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "O'Connor L."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Ho Y."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Duewel H.S."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Colwill K."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Moore L."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Chu P."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Moran M.F."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Ethier M."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Figeys D."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Morin G.B."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Lambert J.P."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Bukhman Y.V."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Robinson M.D."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Topaloglou T."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Kinach R."xsd:string |
| http://purl.uniprot.org/citations/17353931 | http://purl.uniprot.org/core/author | "Climie S."xsd:string |